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Preclinical and laboratory evidence of NAD(+) precursors in health, disease, and ageing [PMID: 34517020] Laboratory literature summary: Preclinical and laboratory evidence of NAD(+) precursors in health, disease, and ageing

A Phase I oral safety trial has been completed [9] , and a small human case series reported improvements following intra-articular administration [5]

Mechanisms of Action (Proposed) Promotes nitric oxide synthesis and activates pathways involved in tissue repair and angiogenesis268

Purpose-formulated topical preparations or sterile application techniques would be preferable to potentially introducing contaminants to open wounds