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The signaling cascade initiated by VEGF, particularly through the VEGF/Nrp-1 pathway, holds paramount importance for angiogenesis within the CNS
IDO-1 is found in various immune cells, including dendritic cells and macrophages, where it suppresses immune function by depleting tryptophan an amino acid vital for T-cell activity and generating immunosuppressive byproducts such as kynurenine
doi: 10.3168/jds.S0022-0302(06)72391-8 77 LoerchS
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