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The mechanism underlying these prosocial effects involves Melanotan II's activation of melanocortin-4 receptors (MC4R) located on oxytocin neurons in the paraventricular nucleus of the hypothalamus

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In fact, in an analogous class B receptor, the parathyroid hormone receptor-1 (PTH1R), the ECD can adopt more than one conformation while bound to a long-acting PTH analog and in the Gs-coupled state 5

Hepatology 75 , 140153 (2022)