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Finally, in 2023 the World Health Organization issued a guideline recommending against the use of non-sugar sweeteners for weight control or to reduce the risk of chronic disease, after a review found no long-term benefit for body fat and a possible association with type 2 diabetes and cardiovascular disease in long-term observational data
No genotoxicity, mutagenicity, or organ-specific toxicity was reported at the doses tested in the preclinical safety evaluation
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