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25 Patients diagnosed with vitamin B 12 deficiency whose history and physical examination do not suggest an obvious dietary or malabsorptive etiology should be tested for pernicious anemia with anti-intrinsic factor antibodies (positive predictive value = 95%), particularly if other autoimmune disorders are present
The author is also grateful to Professor Jon Fraenkel for DSIP data from 1984 to 2010, adapted from The political economy of economic reform in the Pacific
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