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The GLP1-RAs class has grown in the last decade with several agents available for usein the market, Since the efficacy and tolerability, dosing frequency, administration requirements, and cost may vary between agents within the class, each agent may offer unique advantages and disadvantages
In mice fed HFD, TMAO supplementation exacerbated glucose intolerance, induced adipose tissue inflammation, and promoted insulin resistance (154)
Follow-up Duration : While trials extend to 72 weeks or longer, the chronic nature of obesity requires decades-long, unavailable safety and efficacy data
[31] Boehringer Ingelheim
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