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Involvement of Rho-associated kinase (ROCK) The Rho family (Pho, Cdc42, Rac, and Rnd) belongs to the Ras superfamily of low molecular weight G proteins and is a major regulator of the actin cytoskeleton [76,77,78,79,80]
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11 Thus, the latter functions as both an ally and a rival in T2DM, depending upon the glucose status, the stage in the natural history of the disease, and the degree of GIP-1 presence in the system
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