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Formulation Considerations GHK-Cu is generally best suited for gentle, water-based formulations and is typically avoided in highly acidic formulations containing: Strong exfoliating acids Low-pH formulations High-strength Vitamin C formulations Low-pH environments may destabilize the copper-peptide complex and influence formulation stability

Thus, overall, polysomnographic studies indicate greater sleep efficiency with DSIP administration, it has probably not major observed effect on short-term treatment of chronic insomnia

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