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Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose approximately two and four times the clinical dose, respectively, based on measured drug exposure (AUC)
In comparison, the average cup of coffee contains 95 mg of caffeine, so this isn't considered a large amount unless you're especially sensitive to the effects of caffeine
Food intake was meticulously measured visually on a 10-point scale by a blinded experimenter to avoid bias, assessing the proportion of food consumed
Antiarrhythmic sotalol, occlusion/occlusion-like syndrome in rats, and stable gastric pentadecapeptide BPC 157 therapy
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