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Small impurities, residual solvents, or peptide fragments can induce cytotoxic effects or non-specific signaling that mask subtle synaptic changes
In turn, cyclic AMP may activate other signaling pathways
The same research team also found that ONO-8815Ly prevented cartilage degeneration in ACLT and DMM-induced cartilage traumatic models, which was associated with restraining the expression of MMP13, a catabolic factor to matrix network (124)
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