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In other words, high levels of lactate in the GBM TME modulates RNA splicing only in the Treg cell (Foxp3-dependent, meaning it does not affect RNA splicing in other T-cells) to increase CTLA-4 expression on the Treg cell surface, thus enhancing its immunosuppressive effects and preventing effector T-cells from infiltrating and attacking the GBM tumor cells
Amino Acids , 41 (2), 507515
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Kopetz S , Spira AI, Wertheim M, Kim E, Tan BR, Lenz HJ, Nikolinakos P, Rich P, Smith DA, Helwig C, Dussault I, Ojalvo L, Gulley JL
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