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Some substances get punted to February 2027 or later if the committee feels the data are insufficient
Damman ~ BMC Gastroenterology
The standard body surface area scaling method, endorsed by the FDA for first-in-human dose estimates, typically divides the rodent dose by a factor of approximately 6.2 when converting from rat to human
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Avoid Unnecessary Medications Certain medications, notably nonsteroidal anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), and antibiotics , have been shown to disturb the delicate balance of gut microbiota which in turn can increase intestinal permeability
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