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Understanding what is driving that change, and whether it is safe to load the tissue, is the central practical question for anyone training on BPC-157

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The program stands in direct contrast to the Starglo case above: where Starglo's geographic concentration became a liability during FDA review, PURPOSE 1's deliberate recruitment among the population most affected by the disease became a central part of the approval narrative, illustrating that disease-burden-aligned trial design can function as a scientific and regulatory asset rather than merely a compliance obligation

4a) has been deposited in the Proteomics IDEntifications database via the PRIDE partner repository with the dataset identifier PXD045019