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This dual agonism leads to enhanced appetite suppression and more profound metabolic improvements compared to GLP-1 agonism alone

Metabolic adaptation : The body naturally adapts to weight loss by reducing metabolic rate, a phenomenon sometimes called "adaptive thermogenesis." This biological response is expected and can slow or plateau weight loss even when medication and lifestyle factors remain consistent

Peptide Therapy Primer Discover how peptides can transform your health and vitality

Patients treated with semaglutide have experienced considerable weight loss, with long-term use helping maintain it (Wilding et al., 2021)