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Exenatide was the worlds first clinically used GLP-1RA, developed in 1995 and approved for the treatment of type 2 diabetes mellitus (T2DM) in 2005 due to its proven ability to regulate postprandial glucose levels effectively (Furman, 2012)

Rybelsus Rybelsus, another semaglutide drug made by Novo Nordisk, is an oral GLP-1 receptor agonist prescribed to treat type 2 diabetes