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The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models
[2] [7] Risk stratification using FIB-4 in primary care, with second-line tests such as the Enhanced Liver Fibrosis (ELF) test or transient elastography when indicated, helps identify those who may need specialist referral
Hydration-Focused Formula
Nature 508 , 108112 (2014)
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