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Repeated dosing (23 times per week) has proven both safe and effective

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk

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During the COVID-19 pandemic, many patients experienced challenges in accessing their regular injections, with some GP practices stopping injections temporarily or changing patients to oral tablets, resulting in significant anxiety and a return of symptoms for some patients[30]