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Many patients reach meaningful weight loss at the 0.5 to 0.75 mg dose range during the three-month window, while others require the full 1.0 mg maintenance dose for optimal results
Bachmann, I
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One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition
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