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2.3.4 Other nanoparticles that reprogram TAMs In addition to TLR agonists and signaling pathway inhibitors or activators, there are various other nanoparticles that have been shown to exert anti-tumor effects by targeting TAMs and reprogramming M2 TAMs into M1 TAMs

For patients also taking insulin or sulfonylureas, it's important to check blood glucose levels when feeling cold, as hypoglycemia can present with cold, clammy sensations

No washout period is needed between the two medications