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Discontinuing the medication often results in partial or full weight regain within 6 to 12 months, as the appetite-suppressing and metabolic effects of GLP-1s are no longer active

Retatrutide is a peptide therapy with potential effects on: weight loss metabolic health insulin sensitivity appetite regulation energy balance It is often described as a triple agonist peptide because it interacts with three hormone receptors involved in metabolism: GLP-1 GIP glucagon These pathways play an important role in hunger signaling, calorie utilization, and blood sugar control

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Furthermore, GLP-1R has also been localized to mouse aortic smooth muscle and endothelial cells, as well as monocytes and macrophages (188)