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If someone wants rapid, large weight loss, prescription injectable medicines like semaglutide (injectable) or tirzepatide (injectable) produce much larger average reductions in controlled trials, though they are a different category of therapy and come with their own tradeoffs
Improved kidney function: Recent developments in the management of T2D have identified the use of GLP-1s to reduce the progression of kidney disease in individuals with diabetes
J Bone Miner Res
5,8 Recent data from an observational Japanese study of oral semaglutide users found that sleeping more than six hours per night and improving sleep quality during treatment were independently associated with greater odds of achieving at least 3 percent weight loss, whereas severe stress, late-night dinner after 9 pm, and sleeping within three hours of dinner were linked with poorer weight loss outcomes
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