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GIP (Glucose-Dependent Insulinotropic Polypeptide) This is also activated by: Mounjaro (tirzepatide) GIP appears to: improve insulin sensitivity enhance satiety alongside GLP-1 reduce body fat improve glucose control make weight loss more sustainable Researchers believe GIP helps reduce some of the gastrointestinal side effects often experienced with GLP-1 medicines, although this continues to be investigated
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In a patient whose biliary excretion is already compromised, that increment is not trivial
On one hand, GLP-1 activates PKA, increasing the expression of Pdx1 and causing Pdx1 to translocate into the nucleus
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