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The mechanism relates to altered gut motility and changes in fluid balance within the intestines

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Abnormal (dysbiotic) gut microbiota could account for leaky gut and inflammation in older adults (3, 9), since dysbiotic microbiota can produce metabolites that interact with the hosts intestinal epithelial cells to reduce epithelial barrier proteins like zonulin-1 ( Zo1 ), occludin ( Ocln ), and claudins, resulting in disrupted cell-to-cell connections, which compromises intestinal permeability (10, 11)

Participants taking the highest 12 mg dose of retatrutide lost an average of 28.3% of their body weight (31.9 kg) over 80 weeks, while those on the lowest 4 mg dose lost an average of 19.0% of their body weight (21.4 kg)