Most common causes of the discolouration include: Medications amino-salicyclic acid derivatives mesalazine/paraaminosalycylic acid/sulfasalazine doxorubicin , hydroxocobalamin , ibuprofen, phenothiazines, phenolphthalein, propofol , rifampicin/rifampin Dietary ingestants beeturia , rhubarb, blackberries, food dyes Metabolic abnormalities porphyria , urate crystals Hydroxocobalamin Early features of cyanide poisoning include nausea, vomiting, headache, dyspnoea, tachypnoea, hypertension, tachycardia, collapse and seizures
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Immune cells like macrophages and neutrophils, while essential for pathogen clearance, can also contribute to lung injury when overactivated, highlighting the need for therapeutic strategies to modulate ferroptosis