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Yet, the efficiency of such interventions is, in many cases, limited, and additional, second-line treatments are frequently implemented, that mainly involve the use of metformin, as insulin-sensitizer, with variable efficacy in terms of improvement of reproductive and metabolic alterations
As a result, altered intracellular glutathione homeostasis has been widely used as an indicator of oxidative stress
When adverse effects occur, they may include mild skin reactions, gastrointestinal disturbance, or headache, typically following high-dose intramuscular injections rather than oral supplementation
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