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Unfortunately, theres no one-size-fits-all answer here

[16] DPP-4 inhibitors (such as sitagliptin), which enhance incretin activity through a different mechanism Insulin therapy, particularly if oral agents and other injectables are unsuitable Traditional agents like metformin, sulphonylureas, or pioglitazone, depending on individual circumstances NICE guideline NG28 recommends individualised treatment approaches based on HbA1c targets, cardiovascular risk, renal function, and patient preferences

Zhang Y, Parajuli KR, Fava GE et al (2019) GLP-1 receptor in pancreatic alpha-cells regulates glucagon secretion in a glucose-dependent bidirectional manner

For example, one animal study led researchers to conclude that the gastroprotective benefits of BPC-157 are dependent on the route of administration