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As one of the newer agents within the class, the safety of semaglutideboth the subcutaneous and oral formulationhas been scrutinized in the phase 3 programs and CVOTs

4 The deposition of ectopic fat caused by obesity can lead to biological dysfunction of skeletal muscles, including inflammation, insulin resistance (IR) and oxidative stress

A concern is that an upsurge in off-label use of semaglutide will again impart further hardship on people utilising this drug for type 2 diabetes as stock is only guaranteed for expected use in [this cohort]. Moreover, Dr Deed is also wary about siloing healthcare into commercial disease-focused entities as they may impact on patients ability to manage any safety concerns or risks associated with medical advice given in these contexts

Thermal limits: Avoid sustained temperatures above 30C