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These are pathway-level markers: they never predict response to a particular drug, but they map the biology a clinician is prescribing into
GoF receptors are often characterised by a greater propensity for G protein versus -arrestin recruitment and signalling, slower rate of receptor internalisation and rapid recycling back to the plasma membrane, with these characteristics being independent of their surface expression levels (Liu et al., 2022)
doi: 10.3389/fendo.2021.694284
GHK-Cu modulates matrix genes in a model is a mechanistic finding
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