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Research has characterised MT-1s ability to confer photoprotection through mechanisms operating independently of melanin synthesis , documenting enhanced nucleotide excision repair activity, reduced cyclobutane pyrimidine dimer accumulation following UV challenge, and antioxidant pathway upregulation in MT-1-treated melanocytes and keratinocytes

It is common in populations whose diet is dominated by refined rice, white potatoes, or cassava and lacking in meat, fat, and vegetables

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