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Until clinical trials provide the necessary safety and efficacy data, conservative approaches grounded in existing evidence serve patients, clients, and the wellness community most effectively
Studies examining body composition changes during GLP-1 therapy, including the STEP trials (semaglutide) and SURMOUNT-1 (tirzepatide), have demonstrated that approximately 2540% of total weight lost may come from lean body mass, including skeletal muscle, rather than exclusively from fat mass
Abbreviations : RyR1 , ryanodine receptor type 1
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