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By 2050, the burden of stroke in individuals (aged 65 years) will increase significantly: 104.7% in incidence, 218.5% in prevalence, 100.0% in mortality, and 58.9% in DALYs (54)
Those taking GLP-1 medications alongside insulin or sulfonylureas should be aware of an increased risk of hypoglycaemia and may need dose adjustments of these other medications
Further research is needed to fully understand the similarities and differences in the cardioprotective effects of GLP-1RAs and SGLT2 inhibitors
For pediatric patients, a study investigating liraglutide treatment in a male with a homozygous LOF MC4R variant (c.750_751del p.Ile251fsTer34) - accompanied by severe insulin resistance, non-alcoholic fatty liver disease, and obstructive sleep apnea - has also indicated therapeutic benefits [69]
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