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The biggest concern is safety
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The decrease in hyperglycaemia after administration of GLP-1 or GLP-1MK-801 was not associated with changes in plasma insulin levels (Extended Data Fig
The results paved the way for liraglutide, branded as Saxenda, to be approved in the US as a once-a-day subcutaneous injection in December 2014 and in Europe in 2015 for the treatment of chronic weight management combined with a reduced calorie diet and increased physical exercise (Molteni, Chen)
In-person visits at a local clinic help ensure that your GLP-1 injections are administered safely and effectively
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