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Nausea, vomiting, and diarrhea were typically the most common gastrointestinal adverse events, occurring in up to 48.4%, 23.2%, and 23.1% of participants, respectively, with events occurring predominantly during dose escalation and decreasing over time [10, 37, 43, 45,46,47]

PMID: 26908853, PMCID: PMC5360717, DOI: 10.1161/circoutcomes.116.002673