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The short half-life of native GLP-1, typically only 12 min due to rapid degradation, has facilitated the development of structurally modified GLP-1 analogs with longer half-lives, such as liraglutide, exendin-4, and dulaglutide, which exhibit 97%, 53%, and 90% sequence homology, respectively 12
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For instance, in March 2025, ClinicalTrial.gov reported 1,248 ongoing clinical studies focused on monoclonal antibodies in the U.S
