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In a primary prevention study among 3,629 cognitively healthy older adults, the Prevention of Alzheimers Disease by Vitamin E and Selenium (PREADViSE) trial, vitamin E supplementation (400 IU/day of supplemental all - rac --tocopheryl acetate [180 mg/day of RRR --tocopherol]) for a mean of 5.4 years had no benefit on prevention of dementia (113)
Cyano-B12 is the most commonly used, and cheapest, form of B12 with no substantial evidence that other forms are more effective in improving B12 status
Therefore, it is of critical importance that the extracellular glutamate concentration must be kept enough low due to the toxicity of glutamate in high concentrations
