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Earlier animal studies with malnourished mothers reported that delayed ossification is associated with decreased maternal body weight, and maternal malnutrition or reduced intake are common pathways to decreased fetal weight/growth and ossification (6669), but malnutrition models did not report the increase in major congenital anomalies reported after gestational exposure to GLP-1 agonists

It has been shown to work for other types of tendon injury, such as tennis elbow and patellar tendinopathy

B12 supports intestinal mucosal integrity and is itself absorbed through the GI tract the injectable route in this formulation bypasses any absorption compromise entirely

This difference in mechanism is precisely why researchers became so interested in combining cagrilintide with GLP-1 therapy