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Gastrointestinal side effects are by far the most prevalent during early treatment: Nausea Very common (may affect more than 1 in 10 people), typically peaking during the first week and often improving over two to four weeks [1] [2] Vomiting Common (may affect up to 1 in 10 people), usually occurring alongside nausea [1] [2] Diarrhoea Common, may persist for several weeks Constipation Common, sometimes alternating with diarrhoea Abdominal pain or discomfort Common, ranging from mild cramping to more pronounced discomfort Dyspepsia (indigestion) Common Eructation (belching) Common Reduced appetite A therapeutic effect that may feel uncomfortable initially, affecting eating patterns These symptoms arise because semaglutide mimics the natural GLP-1 hormone, which slows gastric emptying and increases satiety

Although it is challenging to develop individualized therapeutic regimens, personalized medicine, such as genetics and biomarker testing, can be used to tailor therapies to patients specific conditions, thereby improving the safety and efficacy of treatments (Sugandh et al., 2023)

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I love this journal because it encourages consistency and helps you recognize non-scale victoriesnot just the number on the scale