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GSH is capable of scavenging ROS through Nrf2-mediated heme oxygenase-1 induction and enhancing M1-like macrophage polarization regulation, showing that GSH may be a useful strategy to increase the human defense system (Mittal et al., 2014
doi: 10.3389/fendo.2023.1234824 6 WuDChenL
Funding The author(s) declare financial support was received for the research, authorship, and/or publication of this article
Interestingly, decreased expression of hephaestin and FPN and increased expression of hepdicin (a protein that promote FPN degradation) suggest these cells accumulate iron and this may contribute to disease worsening
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