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Male rats, oral LD50: 4900 mg/kg
The speed of substitution reflected both the widespread use of the drug (it was among the top-selling drugs in the world) and the highly competitive nature of the generic supply chain for a product that manufacturers had been preparing to enter for years
GIP and GLP-1 exert their effects by binding to their specific receptors, the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), and increasing the level of intracellular cyclic adenosine monophosphate (cAMP), in pancreatic cells
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