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When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA
A The difference in symptom severity may be due to genetic and biological differences, such as the structure of red blood cells, metabolism, biochemistry, and testosterone levels
resulting in better sleep, eases minor aches & pains, and may help bring iron levels within the normal range
Bone demineralisation in a large cohort of Wilson disease patients
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