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Plus, real-world adherence data from Blue Health Intelligence and a 2025 study in JAMA Network Open show that roughly 30 percent of patients discontinue within the first month and over half quit within three months with physical discomfort cited as a primary driver. However, with the exception of nausea, Carroll explains that what often tips a patient toward wanting to discontinue the medication isnt one severe symptom

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Key Takeaway: Supplements are most effective when they are part of a holistic approach that includes high-quality formulations, proper timing, and a lifestyle that supports your goals