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Nutritional strategies should emphasize whole foods, adequate protein intake (0.81.0 g/kg body weight, adjusted for kidney function if needed), and mindful portion control rather than severe caloric restriction, which can further suppress metabolic rate
The evidence base for retatrutide remains limited compared to fully licensed medicines, given its investigational status
These are hypothesis-generating signals, vulnerable to confounding by indication and healthy-user effects, but they were strong enough to justify large prospective trials
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