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doi: 10.1016/j.jacc.2020.02.056 258 KernanWNViscoliCMFurieKLYoungLHInzucchiSEGormanMet al
Some feel them more prominently after the first dose, while for others, it takes a few injections before the detoxification and adaptation processes truly kick in
Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]
Dose escalation, which is standard practice with most GLP-1 medications, helps to optimise therapeutic effects whilst minimising gastrointestinal side effects
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