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The stronger question is not which is better? but which compound fits the research question? A dual receptor model and a triple receptor model answer different research questions
Cells were incubated with the agonist for 15 min (except in the case of KRAS assays, where the incubation time was 60 min), and bioluminescence resonance energy transfer (BRET) measurements were taken using a Victor X4 plate reader (PerkinElmer) immediately after the addition of coelenterazine h (final concentration: 1 M)
The research is exciting, but there are not head-to-head trials on oral vs injectable semaglutide to evaluate CV risk reduction, so diagnosis, dose, cardiovascular history, diabetes status, medication access, side effects, and long-term monitoring all shape the right plan
