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Glutathione is a small but powerful tripeptide made from three amino acids: cysteine, glycine, and glutamate

To determine whether GSSG-induced TNF hepatotoxicity is associated with inhibition of the NF-B signaling pathway, we first examined the effects of H 2 O 2 , BCNU, and diamide treatment on TNF-stimulated NF-B activation

doi:10.1007/978-1-4419-7104-3_4

Glutathione, GSH, Glutathione-SH31 [2] 5 mMGSSG, Glutathione-S-S-Glutathione [3] 0.510 mM1/1001/1000 (GSH) (glutathione disulfide, GSSG)298%GSH [] (L--glutamyl-L-cysteinyl-glycine)---- [] 2 2 [] 1NADPH: GSSG + 2 e 2 GSH: 240 mV [4] ) S-(S-)S- (H2O2)(S-)S- 2 -()2 [] -S- (GSTs) I II D- [] [] -2---- [] --- [] --2- [5] [] [] 2016 (RCT) 2RCT1 [6] [] (5-) () [7] [] (phorone) (glutathione depletor) [8] [9] [10] 10201488 [11] [] [] Merck Index , 11th Edition, 4369