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For example, studies should consider removing any blanket exclusions on patients with: Cognitive or physical disabilities Diagnoses of HIV or hepatitis Substance abuse disorder Other comorbidities that are generally considered exclusion criteria This entails precisely addressing what can be excluded or included in a study and making the protocol as specific as possible so clear judgments can be made on an individual basis

The case of Eli Lillys tirzepatide suggests we may be approaching a ceiling in terms of efficacy: aiming for weight loss beyond 20% might be neither necessary nor clinically sound

doi: 10.1507/endocrj.EJ25-0087 15 LoombaRHartmanMLLawitzEJVuppalanchiRBoursierJBugianesiEet al

Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer's disease mouse model