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In addition, CTN induced ferroptosis of human liver cancer HepG2 cells by significantly enhancing ROS accumulation, reducing GSH level, and downregulating the xCT and GPX4 expression, which could be inhibited by ferrostatin-1 (Fer-1, ferroptosis inhibitor) (Liu JL

However, these are merely early signals, and robust finding regarding efficacy cannot be made until the results of larger randomized controlled trials with determining endpoints come about

Nevertheless, observational studies such as these cannot determine whether low levels of vitamin B12 were the cause of the weight gain or whether higher levels of vitamin B12 protected against lower levels

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