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GSH is synthesiszed via two ATP-dependent processes that are catalysed by -Glu-Cys synthetase (GSH1) and GSH synthetase (GSH2), and it is mostly degraded by -Glutamyl transpeptidases (-GT), which split GSH into cysteinyl-glycine (Cys-Gly) and Glu residue
Following this, DA is stored in synaptic vesicles after uptake by the vesicular monoamine transporter 2 (VMAT2)
Evidence and approval status differ sharply
The loss of DJ-1-mediated maintenance of the transsulfuration pathway could render microglia more vulnerable to ferroptotic damage, thereby linking its classical cytoprotective role in redox homeostasis directly to the emerging pathway of ferroptosis in neurodegeneration
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