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Furthermore, defects in IFN- signaling, often due to loss-of-function mutations in JAK1/2 or STAT1, impair human leukocyte antigen (HLA) upregulation, diminish PD-L1 expression and impede T-cellmediated antitumor responses, thereby conferring resistance to ICB
A 3-week washout improved my HRV by 40%, and that improvement persisted when I restarted at lower doses
10.2165/00044011-200525060-00005 Clin Drug Investig
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