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It plays a fundamental role in providing 70% of the hearts energy from fat breakdown i.e., energy metabolism
All statistical tests used in this study are described in detail in the corresponding figure legends
Research uses MT-1 to establish the reference pharmacodynamic profile for MC1R activation , characterising concentration-response relationships, receptor internalisation kinetics, and downstream melanin synthesis biology that serve as the benchmark for evaluating other melanocortin agonists and antagonists at MC1R
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